Current Topics in Biochemistry

Abstracts selected for Oral Presentation

1) VIRTUAL SCREENING OF HUMAN GLUTATHIONE PEROXIDASE 4 (GPX4): UNDERSTANDING THE CHLOROACETAMIDE CLASS AS INHIBITORS
Presenter: Glorister Alves Altê (Master’s student PPGBQA UFSC) / Abstract Altê G.A.
Data and time: November 11th, 4 – 4:20 p.m.

2) THIOREDOXIN REDUCTASE-1 LEVELS ARE ASSOCIATED WITH NRF2 PATHWAY ACTIVATION AND TUMOR RECURRENCE IN NON-SMALL CELL LUNG CANCER
Presenter: Karoline Almeida Lima (Master’s student PPGBQA UFSC) / Abstract Lima K.A
Data and time: November 11th, 4:20 – 4:40 p.m.

3) miR-425-5p AS AN EXOSOMAL BIOMARKER FOR METASTATIC PROSTATE CANCER.
Presenter: Dra. Adny Henrique Silva (Post-doctoral fellow PGFAR UFSC) / Abstract Silva A.H
Data and time: November 11th, 4:40 – 5:00 p.m.

4) TOXICOLOGICAL EVALUATION IN C. elegans OF AZT DERIVATE WITH- ORGANIC CHALCOGEN: AS A POSSIBLE COVID-19 DRUG CANDIDATE
Presenter: Gabriel Pedroso Viçozzi (Ph.D. candidate UNIPAMPA) / Abstract Viçozzi G.
Data and time: November 11th, 5:00 – 5:20 p.m.

5) INFLUENCE OF 17β-ESTRADIOL ON TESTICULAR ENERGY METABOLISM AND POSSIBLE IMPLICATIONS ON SPERMATOGENESIS IN ZEBRAFISH
Presenter: Hemily Batista-Silva (Ph.D. candidate PPGBQA UFSC and University of Caen, France) / Abstract Batista-Silva H
Data and time: November 12th, 3:00 – 3:20 p.m.

6) ARE THE ANTI-INFLAMMATORY AND METABOLIC EFFECTS OF MOMETASONE FUROATE DEPENDENT ON GLUCOCORTICOID RECEPTOR ACTIVATION?
Presenter: Priscila Zimath (Ph.D. candidate PPG Farmacologia UFSC) / Abstract Zimath P.L
Data and time: November 12th, 3:20 – 3:40 p.m.

7) TETRAHYDROBIOPTERIN AS A KEY FACTOR PROMOTING COLITIS ABDOMINAL PAIN.
Presenter: Dra. Ananda Staats Pires (Post-doctoral fellow Macquarie University) /Abstract Staats Pires A
Data and time: November 12th, 3:40 – 4:00 p.m.

8) MUTANT P53 AND ERK1/2 MAPK COOPERATE WITH THE PRODUCTION OF TNBC INFLAMMATORY SECRETOME
Presenter: Raquel Nascimento das Neves (Ph.D. candidate PPGBQA UFSC) / Abstract das Neves R.N
Data and time: November 12th, 4:00 – 4:20 p.m.

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Abstracts selected for video-poster

Bioinformatics and Structural Biochemistry

Poster 1: FABP4 fatty acid uptake and transport in humans: an in silico study model
Keywords: FABP, Fatty acids, Molecular dynamics, Coarse-grained, Bioinformatics
Presenter: Karin dos Santos
Abstract Santos K. / Video / Meeting

Poster 2: Modulation of Akt1/mTOR pathway contributes to the in vivo anti-tumor effect of benznidazole predicted by in silico simulations
Keywords: Benznidazole, Molecular dynamics, Akt/mTOR pathway, Anti-tumor effect
Presenter: Rodrigo Costa Zeferino
Abstract Zeferino RC/ Video / Meeting

Poster 3: Characterization of the DNA binding domains of the nuclear receptor superfamily in Crassostrea gigas: An in silico analysis
Keywords: Nuclear receptor, DNA binding domain, target genes, Cytochrome P450, NR5A
Presenter: Theo Brascher
Abstract Brascher T.C / Video / Meeting

Poster 4: In silico structural characterization of oyster Crassostrea gigas glutathione S-transferases: isoform candidates for CDNB binding
Keywords: GSTs, Xenobiotic, Molecular Docking, 1-chloro-2,4-dinitrobenzene
Presenter: Júlia Ferreira
Abstract Ferreira J/ Video / Meeting

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Toxicology

Poster 5: Liposomes improve the bioavailability and efficacy of Purple Pitanga extract in aβ aggregation model in vivo
Keywords: Eugenia uniflora; DAF-16; Superoxide dismutase; Amyloid-beta; C.elegans.
Presenter: Flávia Suelen de Oliveira Pereira
Abstract Pereira F.S.O/ Video / Meeting

Poster 6: Biogenic synthetized Fe3O4@Ag nanoparticles cause reprotoxicity dependent of apoptosis in Caenorhabditis elegans
Keywords: Nanotoxicology; Metals; Nanoparticles; Reprotoxicity; C. elegans.
Presenter: Aline Castro Silva
Abstract Silva A.C/ Video / Meeting

Poster 7: Simulating a real scenario of exposure with a solvents mix and evaluating the long term effects in Caenorhabditis elegans model
Keywords: Healthspan; Locomotion; Environment; Toxicity.
Presenter: Marcell Soares
Abstract Soares M.V. / Video / Meeting

Poster 8: Effect of tert-butyl hydroperoxide on the survival of different mutant strains of Caenorhabditis elegans
Keywords: C. Elegans, Oxidative stress, Survival, Peroxide, Mutant strain, Antioxidant protein.
Presenter: Leonardo Vieira
Abstract Vieira L / Video / Meeting

Poster 9: Evaluation of antitumor action of Bougainvillea glabra Choisy Bract extract in Caenorhabditis elegans
Keywords: Alternative model; Hyperplasia; Bract extract, let-60.
Presenter: Maria Eduarda Oliveira de Souza
Abstract Souza M.E.O. / Video / Meeting

Poster 10: Induction of photoaging by ultraviolet radiation in Caenorhabditis elegans
Keywords: UV-A radiation; Photoaging; Caenorhabditis elegans.
Presenter: Paula Trevisan
Abstract Trevisan P./ Video / Meeting

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Metabolism

Poster 11: Intracellular damage markers in the intestinal epithelium of larval Callosobruchus maculatus fed on common bean (Phaseolus vulgaris)
Keywords: Antibiosis; Endocytosis; Oxidative stress; Glutathione; α-amylase.
Presenter: Samira Pietrobom Ibrahim
Abstract Ibrahim S.P. / Video / Meeting

Poster 12: Effects at the zootechnical performance, digestive enzyme profiles, oxidative stress, immunological and microbiological parameters of juvenile shrimp L. vannamei fed with a meal of the insect Nauphoeta cinerea (NC)
Keywords: Shrimp; Enzyme; Entomophagy; Edible insect.
Presenter: Cristina Rios
Abstract Rios C./ Video / Meeting

Poster 13: Effects of the inhibition of microglial cell reactivity on brain dysfunctions related to diet-induced hypercholesterolemia in mice
Keywords: Hypercholesterolemia; Neuroinflammation; Microglia; Minocycline.
Presenter: Tainá Schons
Abstract Schons T. / Video / Meeting

Poster 14: Blood tetrahydrobiopterin metabolism metabolites in COVID-19-affected individuals
Keywords: SARS-CoV-2; Inflammation; Biomarkers; Tetrahydrobiopterin; Neopterin.
Presenter: Jennyffer Souza
Abstract Souza J/ Video / Meeting

Poster 15: BH4 in Autism Spectrum Disorders: an unexplored avenue
Keywords:
Keywords: Tetrahydrobiopterin; Autism; ASD; BH4 pathway.
Presenter: Clóvis Lopes Colpani Filho
Abstract Colpani Filho C.L/ Video / Meeting

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Cell Signaling

Poster 16: Selenylated imidazo[1,2-a]pyridine causes mitochondrial dysfunction and ERK signaling inhibition effect in glioblastoma cells
Keywords: Imidazo[1,2-a]pyridine; Selenium compound; Glioblastoma; MAPK/ERK signaling pathway.
Presenter: Daniela Coelho dos Santos
Abstract Santos D.C. / Video / Meeting

Poster 17: Lauric acid prevents the production of IL-8 and IL-13 and increase of kynurenine/tryptophan ratio in LPS-stimulated human astrocytes
Keywords: Lauric acid; Inflammation; Tryptophan; Kynurenine pathway; cytokine.
Presenter: Michelle Garcez
Abstract Garcez M.L./ Video / Meeting

Poster 18: Inflammatory status in patients affected by Amyotrophic Lateral Sclerosis attended at a state referral center
Keywords: Neurodegenerative diseases; Biomarkers; Lou Gehrig’s disease.
Presenter: Gisele Espíndola
Abstract Espindola G./ Video / Meeting

Poster 19: Coffee promotes reduction of cell viability in cutaneous melanoma cells, SK-MEL-28
Keywords: Cell viability; Cutaneous melanoma; Coffee; Caffeine.
Presenter: Daniela Varnier
Abstract Varnier D. / Video / Meeting

Poster 20: Unfitted mitochondria due to reduced hippocampal AMPK activation favors memory impairment and neurodegeneration
Keywords: Neurodegenerative Diseases; Mitochondrial Dysfunctional; Reactive Species.
Presenter: Hugo G. M. Tolentino de Souza
Abstract Tolentino H.G/ Video / Meeting

Poster 21: Melanoma activates intra-tumoral nerves
Keywords: Secretory Leukocyte Protease Inhibitor; Immunoregulation; Nociception; Melanoma.
Presenter: Tuany Eichwald
Abstract Eichwald T / Video / Meeting

Poster 22: Tetrahydrobiopterin Levels as a Quantitative Tool for the Evolution of Crohn’s Disease
Keywords: Crohn’ disease; Inflammation; Pain; Biomarker; Tetrahydrobiopterin.
Presenter: Vivian de Souza Menegassi
Abstract Menegassi V.S/ Video / Meeting

Poster 23: A cell fractionation method to obtain cytoplasmic, nuclear and mitochondrial fractions in the small brain samples.
Keywords: Cell fractionation; Method; Hippocampus; Cerebral cortex.
Presenter: Barbara Santos
Abstract Dos Santos B/ Video / Meeting

Poster 24: Agmatine provides resilience to LPS-induced inflammatory activation and depressive-like behavior in mice
Keywords: Agmatine; Fast-acting antidepressants; Ketamine; Major depressive disorder; Neuroinflammation.
Presenter: Ana Paula Valverde
Abstract Valverde A.P/ Video / Meeting

Poster 25: Effect of blanching on the phenolic compounds and antioxidant activity of Amaranthus deflexus Linn and Pereskia aculeata Miller leaves
Keywords: Amaranthus deflexus Linn; Pereskia aculeata Miller; Blanching; Antioxidant activity; Phenolic compounds.
Presenter: Gleice Reinert
Abstract Reinert G / Video / Meeting

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